{"id":1753,"date":"2015-07-09T22:46:47","date_gmt":"2015-07-09T20:46:47","guid":{"rendered":"http:\/\/www.epitype.de\/?page_id=1753&#038;lang=en"},"modified":"2015-11-12T19:13:16","modified_gmt":"2015-11-12T18:13:16","slug":"faq-physicians","status":"publish","type":"page","link":"https:\/\/www.epitype.de\/en\/information-for-physicians\/faq-physicians\/","title":{"rendered":"FAQ physicians"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_heading-5fbf9b6e6e98ad34f96cf8916c4613ed\">\n#top .av-special-heading.av-av_heading-5fbf9b6e6e98ad34f96cf8916c4613ed{\npadding-bottom:25px;\n}\nbody .av-special-heading.av-av_heading-5fbf9b6e6e98ad34f96cf8916c4613ed .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-av_heading-5fbf9b6e6e98ad34f96cf8916c4613ed .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-av_heading-5fbf9b6e6e98ad34f96cf8916c4613ed av-special-heading-h1 blockquote modern-quote  avia-builder-el-0  el_before_av_textblock  avia-builder-el-first '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >Frequently asked questions &#8211; physicians<\/h1><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<section  class='av_textblock_section av-av_textblock-0366cc7376be6c9e82a3e9cc8987b64f '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" >            <div class=\"qae-faqs-container qae-faqs-list-container\">\n\t\t\t\t\t\t\t<ul class=\"qe-faqs-filters-container\">\n\t\t\t\t<li class=\"active\"><a class=\"qe-faqs-filter all-faqs\" href=\"#\" data-filter=\"*\">All<\/a><\/li>\n\t\t\t\t<li><a class=\"qe-faqs-filter\" href=\"#fuer-aerzte\" data-filter=\".fuer-aerzte\">For Physicians<\/a><\/li>\t\t\t<\/ul>\n\t\t\t<ol class=\"qe-faqs-index-list\"><div id=\"qe-faqs-index\" class=\"qe-faqs-index\">\n\t\t\t\t\t<li class=\"for-physicians\">\n\t\t\t\t\t\t<a href=\"#qaef-1657\">What are human papillomaviruses (HPV)?<\/a>\n\t\t\t\t\t<\/li>\n\n\t\t\t\t\n\t\t\t\t\t<li class=\"for-patients for-physicians\">\n\t\t\t\t\t\t<a href=\"#qaef-1645\">What are low- and high-risk HPV types?<\/a>\n\t\t\t\t\t<\/li>\n\n\t\t\t\t\n\t\t\t\t\t<li class=\"for-physicians\">\n\t\t\t\t\t\t<a href=\"#qaef-1658\">For whom have we developed GynTect\u00ae?<\/a>\n\t\t\t\t\t<\/li>\n\n\t\t\t\t\n\t\t\t\t\t<li class=\"for-patients for-physicians\">\n\t\t\t\t\t\t<a href=\"#qaef-1644\">What does a positive GynTect\u00ae result mean?<\/a>\n\t\t\t\t\t<\/li>\n\n\t\t\t\t\n\t\t\t\t\t<li class=\"for-physicians\">\n\t\t\t\t\t\t<a href=\"#qaef-1659\">How can GynTect\u00ae improve cervical cancer screening?<\/a>\n\t\t\t\t\t<\/li>\n\n\t\t\t\t\n\t\t\t\t\t<li class=\"for-patients for-physicians\">\n\t\t\t\t\t\t<a href=\"#qaef-1648\">What are the advantages of GynTect\u00ae compared to a normal cervical examination?<\/a>\n\t\t\t\t\t<\/li>\n\n\t\t\t\t\n\t\t\t\t\t<li class=\"for-physicians\">\n\t\t\t\t\t\t<a href=\"#qaef-1660\">What are epigenetic markers?<\/a>\n\t\t\t\t\t<\/li>\n\n\t\t\t\t\n\t\t\t\t\t<li class=\"for-patients for-physicians\">\n\t\t\t\t\t\t<a href=\"#qaef-1661\">What are the advantages of GynTect\u00ae compared to a normal cervical examination?<\/a>\n\t\t\t\t\t<\/li>\n\n\t\t\t\t<\/div><\/ol>\t\t<div id=\"qaef-1657\" class=\"qe-faq-list for-physicians\">\n\t\t\t<div class=\"qe-list-title\">\n\t\t\t\t<h4>\n\t\t\t\t\t<i class=\"fa fa-question-circle\"><\/i> What are human papillomaviruses (HPV)?\t\t\t\t<\/h4>\n\t\t\t<\/div>\n\t\t\t<div class=\"qe-list-content\">\n\t\t\t\t<p>Human papillomaviruses are a group of viruses that may evoke warts. All these HPV types differ genetically, and they can infect the skin or mucosal tissue, not only but preferentially in the anogenital region. HPV infections are always locally restricted and do not spread to more distant parts\/organs of the body.<\/p>\n<p>Of the more than 150 types of HPV, a small group, the so-called high-risk human papillomaviruses (hr-HPV), may cause precancerous lesions and, if not diagnosed and treated early, cancer (e. g. cervical cancer, tonsillar cancer).<\/p>\n<br \/><a class=\"qe-faq-top\" href=\"#qe-faqs-index\"><i class=\"fa fa-angle-up\"><\/i> Back to Index<\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div id=\"qaef-1645\" class=\"qe-faq-list for-patients for-physicians\">\n\t\t\t<div class=\"qe-list-title\">\n\t\t\t\t<h4>\n\t\t\t\t\t<i class=\"fa fa-question-circle\"><\/i> What are low- and high-risk HPV types?\t\t\t\t<\/h4>\n\t\t\t<\/div>\n\t\t\t<div class=\"qe-list-content\">\n\t\t\t\t<p>The genital HPV types are classified into two groups: low and high risk HPV. Low-risk HPV (e.g. 6, 11, 42, 43, 44) are almost never detected in case of a cervical cancer. High-risk HPV types (e.g. 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58) are detected in 99.7% of all cervical cancer cases. In 70% of the cases, HPV16 and HPV18 are detected. Only women with long-term infection with high-risk HPV and subsequent cervical lesions have a risk of developing precancerous lesions\u00a0and cancer. It is well-established nowadays that HPV infection ist he main risk factor for the development of cervical cancer.<\/p>\n<br \/><a class=\"qe-faq-top\" href=\"#qe-faqs-index\"><i class=\"fa fa-angle-up\"><\/i> Back to Index<\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div id=\"qaef-1658\" class=\"qe-faq-list for-physicians\">\n\t\t\t<div class=\"qe-list-title\">\n\t\t\t\t<h4>\n\t\t\t\t\t<i class=\"fa fa-question-circle\"><\/i> For whom have we developed GynTect\u00ae?\t\t\t\t<\/h4>\n\t\t\t<\/div>\n\t\t\t<div class=\"qe-list-content\">\n\t\t\t\t<p>According to the already performed trials,\u00a0GynTect<sup>\u00ae<\/sup>\u00a0is suitable for all women who want to get further clarification after an abnormal Pap smear and\/or a positive HPV test, if surgery is already required or if a watchful waiting strategy could demonstrate if an HPV infection and a tissue abnormality may heal without treatment.<\/p>\n<br \/><a class=\"qe-faq-top\" href=\"#qe-faqs-index\"><i class=\"fa fa-angle-up\"><\/i> Back to Index<\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div id=\"qaef-1644\" class=\"qe-faq-list for-patients for-physicians\">\n\t\t\t<div class=\"qe-list-title\">\n\t\t\t\t<h4>\n\t\t\t\t\t<i class=\"fa fa-question-circle\"><\/i> What does a positive GynTect\u00ae result mean?\t\t\t\t<\/h4>\n\t\t\t<\/div>\n\t\t\t<div class=\"qe-list-content\">\n\t\t\t\t<p>Results obtained during clinical trials indicate that upon a positive GynTect<sup>\u00ae<\/sup> test result a severe cervical lesion, a so-called CIN3, or even a cervical carcinoma (from a low-grade CIN1 or CIN2) may develop or already be present. Invasive diagnostics (colposcopy and, if required, biopsy, both in a specialized colposcopy clinic) should be performed after a positive GynTect<sup>\u00ae<\/sup>\u00a0test result. During this examination conspicuous surface of the cervix should be examined very thoroughly, and biopsies taken during this examination should be diagnosed\u00a0by histopathology.<\/p>\n<p>In case of a negative test result a precancerous leson or cancer can almost be excluded. We recommend a re-examination after 6 months, with HPV testing performed\u00a0first.<\/p>\n<br \/><a class=\"qe-faq-top\" href=\"#qe-faqs-index\"><i class=\"fa fa-angle-up\"><\/i> Back to Index<\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div id=\"qaef-1659\" class=\"qe-faq-list for-physicians\">\n\t\t\t<div class=\"qe-list-title\">\n\t\t\t\t<h4>\n\t\t\t\t\t<i class=\"fa fa-question-circle\"><\/i> How can GynTect\u00ae improve cervical cancer screening?\t\t\t\t<\/h4>\n\t\t\t<\/div>\n\t\t\t<div class=\"qe-list-content\">\n\t\t\t\t<p>GynTect<sup>\u00ae<\/sup>\u00a0is a reliable molecular test that may clarify if a patient with unclear Pap test results (Pap III, PAP IIID, evtl. Pap IVa) and\/or an\u00a0HPV infection already has a precancerous lesion of carcinoma that requires treatment.<\/p>\n<p>GynTect<sup>\u00ae<\/sup>\u00a0aims at the detection of specific epigenetic changes that may occur early in cervical carcinogenesis. If these changes are not detectable, watchful waiting may help avoiding unnecessary surgery.<\/p>\n<br \/><a class=\"qe-faq-top\" href=\"#qe-faqs-index\"><i class=\"fa fa-angle-up\"><\/i> Back to Index<\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div id=\"qaef-1648\" class=\"qe-faq-list for-patients for-physicians\">\n\t\t\t<div class=\"qe-list-title\">\n\t\t\t\t<h4>\n\t\t\t\t\t<i class=\"fa fa-question-circle\"><\/i> What are the advantages of GynTect\u00ae compared to a normal cervical examination?\t\t\t\t<\/h4>\n\t\t\t<\/div>\n\t\t\t<div class=\"qe-list-content\">\n\t\t\t\t<p>Additional tests are required in order to clarify if a precancerous lesion or cancer is the reason for an abnormal Pap smear result. GynTect\u00ae is an easy to perform and reliable test which detects epigenetic changes specifically occuring in cancer tissue. The same cervical smear material that is currently used for Pap testing is used for GynTect\u00ae.<\/p>\n<br \/><a class=\"qe-faq-top\" href=\"#qe-faqs-index\"><i class=\"fa fa-angle-up\"><\/i> Back to Index<\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div id=\"qaef-1660\" class=\"qe-faq-list for-physicians\">\n\t\t\t<div class=\"qe-list-title\">\n\t\t\t\t<h4>\n\t\t\t\t\t<i class=\"fa fa-question-circle\"><\/i> What are epigenetic markers?\t\t\t\t<\/h4>\n\t\t\t<\/div>\n\t\t\t<div class=\"qe-list-content\">\n\t\t\t\t<p>If a normal cell develops into a tumor cell, this leaves traces in the genetic material, the DNA, of the tumor cells. Such\u00a0epigenetic traces, a specific methylation of certain DNA regions, are detected with tests developed by oncgnostics. Our studies demonstrate that the markers validated for\u00a0GynTect<sup>\u00ae<\/sup>, can easily be detected in smear material from the cervix of women with disease.<\/p>\n<br \/><a class=\"qe-faq-top\" href=\"#qe-faqs-index\"><i class=\"fa fa-angle-up\"><\/i> Back to Index<\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div id=\"qaef-1661\" class=\"qe-faq-list for-patients for-physicians\">\n\t\t\t<div class=\"qe-list-title\">\n\t\t\t\t<h4>\n\t\t\t\t\t<i class=\"fa fa-question-circle\"><\/i> What are the advantages of GynTect\u00ae compared to a normal cervical examination?\t\t\t\t<\/h4>\n\t\t\t<\/div>\n\t\t\t<div class=\"qe-list-content\">\n\t\t\t\t<p>In oder to determine whether an abnormal Pap smear result originates from a cervical disease requiring treatment, additional\u00a0tests and examinations are required.\u00a0With our\u00a0GynTect<sup>\u00ae<\/sup>\u00a0procedure we reliably identify\u00a0epigenetic changes which occur specifically in cancer tissue. For this test we use the same material that is currently used for the Pap test.<\/p>\n<br \/><a class=\"qe-faq-top\" href=\"#qe-faqs-index\"><i class=\"fa fa-angle-up\"><\/i> Back to Index<\/a>\t\t\t<\/div>\n\t\t<\/div>\n\t\t            <\/div>\n\t\t\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":10,"featured_media":0,"parent":1616,"menu_order":4,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1753","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>FAQ physicians - Epitype GmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.epitype.de\/en\/information-for-physicians\/faq-physicians\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FAQ physicians - 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