{"id":1629,"date":"2015-04-06T21:55:44","date_gmt":"2015-04-06T19:55:44","guid":{"rendered":"http:\/\/www.epitype.de\/?page_id=1629&#038;lang=en"},"modified":"2019-02-07T17:28:02","modified_gmt":"2019-02-07T16:28:02","slug":"trial-data","status":"publish","type":"page","link":"https:\/\/www.epitype.de\/en\/information-for-physicians\/trial-data\/","title":{"rendered":"Trial data"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_heading-9850e4b973d2f450a63e10a3067f60fb\">\n#top .av-special-heading.av-av_heading-9850e4b973d2f450a63e10a3067f60fb{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-av_heading-9850e4b973d2f450a63e10a3067f60fb .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-av_heading-9850e4b973d2f450a63e10a3067f60fb .av-subheading{\nfont-size:18px;\n}\n<\/style>\n<div  class='av-special-heading av-av_heading-9850e4b973d2f450a63e10a3067f60fb av-special-heading-h1 blockquote modern-quote  avia-builder-el-0  el_before_av_textblock  avia-builder-el-first '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >Trial data<\/h1><div class='av-subheading av-subheading_below'><p>Clinical performance of GynTect<sup>\u00ae<\/sup><\/p>\n<\/div><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<section  class='av_textblock_section av-jruu5lsg-9a0944ecc67819f2506c71b4e896138f '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Current data on the performance of GynTect were presented on international conferences.<\/p>\n<ul>\n<li>Data on the prognostic value of GynTect: <a href=\"http:\/\/www.epitype.de\/wp-content\/uploads\/2016\/08\/20150204Eurogin.pdf\" target=\"_blank\" rel=\"noopener\">Eurogin 2015<\/a><\/li>\n<li>Data on the sensitivity and specificity with &gt;500 samples: <a href=\"http:\/\/www.epitype.de\/wp-content\/uploads\/2016\/08\/Eurogin2016.pdf\" target=\"_blank\" rel=\"noopener\">Eurogin 2016<\/a><\/li>\n<li>Data in comparison to CINtec Plus and cobas HPV: <a href=\"http:\/\/www.epitype.de\/wp-content\/uploads\/2018\/02\/Eurogin-2017-talk.pdf\" target=\"_blank\" rel=\"noopener\">Eurogin 2017<\/a><\/li>\n<li>Data in comparison to QIAsure: <a href=\"http:\/\/www.epitype.de\/wp-content\/uploads\/2019\/02\/2018-Dippmann-Eurogin.pdf\">Eurogin 2018<\/a><\/li>\n<li>Data on the sensitivity and specificity with &gt;300 samples, GynTect performed on a cobas Z480 analyzer: <a href=\"http:\/\/www.epitype.de\/wp-content\/uploads\/2019\/02\/2018_Eichelkraut_Eurogin.pdf\">Eurogin 2018<\/a><\/li>\n<\/ul>\n<p>In the triage of women tested HPV-positive, GynTect<sup>\u00ae<\/sup> has a very good sensitivity and specificity.<\/p>\n<p>You&#8217;ll find current publications regarding sensitivity and specificity of GynTect here:<\/p>\n<ul>\n<li>Trial using GynTect in comparison to CINtec Plus and cobas HPV: <a href=\"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-018-5125-8\">Schmitz et al, BMC Cancer 2018<\/a><\/li>\n<li>GynTect Performance on STM samples: <a href=\"https:\/\/clinicalepigeneticsjournal.biomedcentral.com\/articles\/10.1186\/s13148-017-0419-2\" target=\"_blank\" rel=\"noopener\">Schmitz et al, Clin Epigenetics (2017)<\/a><\/li>\n<li>GynTect performance on 100 samples at our partnerlab from Medirex: <a href=\"http:\/\/www.epitype.de\/wp-content\/uploads\/2018\/02\/Eichelkraut2017.pdf\" target=\"_blank\" rel=\"noopener\">Eichelkraut et al, Newslab (2017)<\/a><\/li>\n<\/ul>\n<p>The graph shown in here showes the performance in a blinded observational trial, where data were obtained for the GynTect<sup>\u00ae<\/sup> markers compared to histopathology findings. In this trial all cancer cases were detected by the markers. Furthermore, in patients aged 30 years and older, 90%\u00a0CIN3 were detected by the GynTect<sup>\u00ae<\/sup> markers. This demonstrates\u00a0that GynTect<sup>\u00ae<\/sup> has a very good sensitivity for CIN3 and cancer cases.<\/p>\n<p>Cervical cancer develops very slowly from dysplastic changes. In ongoing studies we want to demonstrate if GynTect<sup>\u00ae<\/sup> detects exactly those dysplastic lesions that have the potential to progress to carcinomas.<\/p>\n<p>These data and data on tissue samples are published here:\u00a0<a href=\"http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0091905\" target=\"_blank\" rel=\"noopener\">Hansel et al, PLoS one (2014)<\/a><\/p>\n<\/div><\/section>\n<section  class='av_textblock_section av-av_textblock-0366cc7376be6c9e82a3e9cc8987b64f '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><div class=\"visualizer-front-container\" id=\"chart_wrapper_visualizer-1732-722688370\"><style type=\"text\/css\" name=\"visualizer-custom-css\" id=\"customcss-visualizer-1732\">.locker,.locker-loader{position:absolute;top:0;left:0;width:100%;height:100%}.locker{z-index:1000;opacity:.8;background-color:#fff;-ms-filter:\"progid:DXImageTransform.Microsoft.Alpha(Opacity=80)\";filter:alpha(opacity=80)}.locker-loader{z-index:1001;background:url(https:\/\/www.epitype.de\/wp-content\/plugins\/visualizer\/images\/ajax-loader.gif) no-repeat center center}.dt-button{display:none!important}.visualizer-front-container.visualizer-lazy-render{content-visibility: auto;}.google-visualization-controls-categoryfilter label.google-visualization-controls-label {vertical-align: middle;}.google-visualization-controls-categoryfilter li.goog-inline-block {margin: 0 0.2em;}.google-visualization-controls-categoryfilter li {padding: 0 0.2em;}.visualizer-front-container .dataTables_scrollHeadInner{margin: 0 auto;}<\/style><div id=\"visualizer-1732-722688370\" class=\"visualizer-front  visualizer-front-1732\"><\/div><!-- Not showing structured data for chart 1732 because description is empty --><\/div>\n<p>CIN = Cervical Intraepithelial Neoplasia. CIN 1 and CIN 2: mild to moderate\u00a0dysplasia; CIN 3: severe\u00a0dysplasia<\/p>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":10,"featured_media":0,"parent":1616,"menu_order":3,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1629","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Trial data - Epitype GmbH<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.epitype.de\/en\/information-for-physicians\/trial-data\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Trial data - Epitype GmbH\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.epitype.de\/en\/information-for-physicians\/trial-data\/\" \/>\n<meta property=\"og:site_name\" content=\"Epitype GmbH\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/oncgnostics\/\" \/>\n<meta property=\"article:modified_time\" content=\"2019-02-07T16:28:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.epitype.de\/wp-content\/uploads\/2015\/03\/oncgnostics-logo2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"340\" \/>\n\t<meta property=\"og:image:height\" content=\"156\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.epitype.de\\\/en\\\/information-for-physicians\\\/trial-data\\\/\",\"url\":\"https:\\\/\\\/www.epitype.de\\\/en\\\/information-for-physicians\\\/trial-data\\\/\",\"name\":\"Trial data - Epitype GmbH\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.epitype.de\\\/en\\\/#website\"},\"datePublished\":\"2015-04-06T19:55:44+00:00\",\"dateModified\":\"2019-02-07T16:28:02+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.epitype.de\\\/en\\\/information-for-physicians\\\/trial-data\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.epitype.de\\\/en\\\/information-for-physicians\\\/trial-data\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.epitype.de\\\/en\\\/information-for-physicians\\\/trial-data\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\\\/\\\/www.epitype.de\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Information for physicians\",\"item\":\"https:\\\/\\\/www.epitype.de\\\/en\\\/information-for-physicians\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Trial data\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.epitype.de\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.epitype.de\\\/en\\\/\",\"name\":\"epitype GmbH\",\"description\":\"Molecular cancer diagnostics\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.epitype.de\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Trial data - Epitype GmbH","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.epitype.de\/en\/information-for-physicians\/trial-data\/","og_locale":"en_US","og_type":"article","og_title":"Trial data - Epitype GmbH","og_url":"https:\/\/www.epitype.de\/en\/information-for-physicians\/trial-data\/","og_site_name":"Epitype GmbH","article_publisher":"https:\/\/www.facebook.com\/oncgnostics\/","article_modified_time":"2019-02-07T16:28:02+00:00","og_image":[{"width":340,"height":156,"url":"https:\/\/www.epitype.de\/wp-content\/uploads\/2015\/03\/oncgnostics-logo2.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.epitype.de\/en\/information-for-physicians\/trial-data\/","url":"https:\/\/www.epitype.de\/en\/information-for-physicians\/trial-data\/","name":"Trial data - Epitype GmbH","isPartOf":{"@id":"https:\/\/www.epitype.de\/en\/#website"},"datePublished":"2015-04-06T19:55:44+00:00","dateModified":"2019-02-07T16:28:02+00:00","breadcrumb":{"@id":"https:\/\/www.epitype.de\/en\/information-for-physicians\/trial-data\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.epitype.de\/en\/information-for-physicians\/trial-data\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.epitype.de\/en\/information-for-physicians\/trial-data\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Startseite","item":"https:\/\/www.epitype.de\/en\/"},{"@type":"ListItem","position":2,"name":"Information for physicians","item":"https:\/\/www.epitype.de\/en\/information-for-physicians\/"},{"@type":"ListItem","position":3,"name":"Trial data"}]},{"@type":"WebSite","@id":"https:\/\/www.epitype.de\/en\/#website","url":"https:\/\/www.epitype.de\/en\/","name":"epitype GmbH","description":"Molecular cancer diagnostics","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.epitype.de\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/www.epitype.de\/en\/wp-json\/wp\/v2\/pages\/1629","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.epitype.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.epitype.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.epitype.de\/en\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.epitype.de\/en\/wp-json\/wp\/v2\/comments?post=1629"}],"version-history":[{"count":0,"href":"https:\/\/www.epitype.de\/en\/wp-json\/wp\/v2\/pages\/1629\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.epitype.de\/en\/wp-json\/wp\/v2\/pages\/1616"}],"wp:attachment":[{"href":"https:\/\/www.epitype.de\/en\/wp-json\/wp\/v2\/media?parent=1629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}